Karakterisasi Peptida Nterm-34 kDa Protein Saliva Nyamuk Aedes aegypti sebagai Kandidat Antigen Biomarker Risiko Transmisi Virus Dengue Secara In Silico
نویسندگان
چکیده
Recently, a new biomarker of mosquito bite has been developed using human antibody response to salivary protein. One the proteins that tested is protein 34-kDa which refined Nterm-34 kDa peptide. This study aimed characterize peptide as potential antigen asses Dengue virus transmission risk. The sequence was analyzed several software predict characteristic BLASTP from Vectorbase and NCBI wa used check specificity IBIVU Praline do multiple alignment. IEDB (Bepipred Kolaskar & Tongaonkar antigenicity prediction) epitopes antigenic properties, lastly, ProtParam physicochemical properties. result showed specific Aedes aegypti at species level low conservation compared other in family. predicted be one epitopes. have molecular weight 2,092 kDa, unstable, hydrophilic. In conclusion, an for transmission.
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ژورنال
عنوان ژورنال: Jurnal Ilmu Kedokteran
سال: 2023
ISSN: ['1978-662X', '2715-4467']
DOI: https://doi.org/10.26891/jik.v17i1.2023.32-40